• Why is HBV cccDNA important?
• How to measure the quantity of cccDNA and determine its transcription activity? Will PCR methods ever be good enough and are we close to standardizing across the leading labs?
• Are the surrogate markers of any good?
• How to choose the best model (cell or animal) to study the production and epigenetic control of cccDNA?
• What are the common pitfalls in applying standard epigenetic methods to study cccDNA?
• What are some of the new approaches to clear or inactive cccDNA?